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Breakthrough Oral Controlled Release Technology For Superior Controlled Therapeutics of Insoluble Drugs

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Conventional controlled release technologies have been designed primarily for water soluble drugs. These technologies can be inherently inefficient for delivery of water insoluble drugs due to inadequate or pH sensitive solubilization and release, and due to "absorption window" limitations. Such limitations can result in inadequate absorption or often leading to reduced efficacy.

Lip'ral Synchronized Solubilizer Release (SSR)   is an extension of the Lip'ral technology platform superimposing controlled release aspects while preserving the solubilizing power and absorption improvement of Lip'ral technology. Lip'ral-SSR synchronizes the release of the insoluble drug and solubilizers and is ideally suited for drugs that require solubilization and controlled release.


  Image  Diverse Release Profiles: Can be modulated for extended release throughout the GI tract or for delayed, extended, pulsatile, or other forms of targeted release.
  Image  pH-independent solubilization: Ideal for acidic and basic drugs requiring consistent absorption throughout the gastrointestinal tract for safety or efficacy.
  Image  Optimization: Utilizes a wide range of proprietary compositions with bioacceptable excipients specifically designed for the physicochemical properties and pharmacokinetic requirements of a particular drug
  Image  Dosage Form Flexibility: In combination with Lipocine's solid lipid dispersion technology, Nanosplode, supports a wide variety of dosage form configurations including capsules, tablets, beads and multicomponent systems for a combination of different release profiles
  Image  Ease of Manufacturing: Uses conventional manufacturing processes that are easy to scale-up and commercialize, thus reducing time to market.

Lip'ral-SSR enables superior products with

  Image  Improved bioavailability/reduced dose
  Image  Reduced dosing frequency/improved patient compliance
  Image  Targeted absorption or chronotherapeutic release



Consider LipidScreen for your target compound.


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